In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract
Joint Authors
Lambert, Joshua
Dabas, Deepti
Elias, Ryan J.
Ziegler, Gregory R.
Source
International Journal of Food Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-24
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Avocado (Persea americana) seeds have been used traditionally for a number of health-related indications.
Because of its high polyphenol content, we investigated the potential antioxidant and anticancer effects of a colored avocado seed extract (CASE).
CASE exhibited an oxygen radical acceptance capacity value of 2012 ± 300 trolox equivalents/mg.
CASE reduced lipid hydroperoxide formation in an oil-in-water emulsion (33% reduction at 500 μg/mL).
CASE dose-dependently reduced the viability of human breast (MCF7), lung (H1299), colon (HT29), and prostate (LNCaP) cancer cells in vitro.
The half maximal inhibitory concentrations ranged from 19 to 132 μg/mL after treatment for 48 h.
CASE treatment downregulated the expression of cyclin D1 and E2 in LNCaP cells.
This was associated with cell G0/G1 phase cycle arrest.
CASE also dose-dependently induced apoptosis in LNCaP cells.
CASE reduced nuclear translocation of nuclear factor κB, a prosurvival signal.
Further studies are needed to examine these effects in in vivo models.
American Psychological Association (APA)
Dabas, Deepti& Elias, Ryan J.& Ziegler, Gregory R.& Lambert, Joshua. 2019. In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract. International Journal of Food Science،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1165377
Modern Language Association (MLA)
Dabas, Deepti…[et al.]. In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract. International Journal of Food Science No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1165377
American Medical Association (AMA)
Dabas, Deepti& Elias, Ryan J.& Ziegler, Gregory R.& Lambert, Joshua. In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract. International Journal of Food Science. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1165377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165377