Plant Enzymes Decrease Prostate Cancer Cell Numbers and Increase TNF-α In Vivo: A Possible Role in Immunostimulatory Activity
Joint Authors
Kang, Ki Mun
Gu, Yeun-Hwa
Yamashita, Takenori
Yamamoto, Hajime
Matsuo, Tatsuhiko
Washino, Noriyuki
Song, Jin-Ho
Source
International Journal of Food Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-28
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Increased caloric intake and Westernized dietary choices may be contributing toward a recent rising trend of incidences of chronic lifestyle-related diseases.
In this study, we evaluated the anticancer properties of Plant Enzyme Validux (PEV) using a mouse model.
Five-week-old male C3H mice were randomly distributed into four experimental groups: Control, PEV only, 6Gy irradiation only, and PEV + 6Gy.
PEV was orally administered daily at 500 mg/kg for 14 days prior to three rounds of 2Gy irradiation.
We focused on the anticancer action and immunostimulatory effects of PEV with and without irradiation.
Oncogene suppression was observed after PEV treatment as was an increase in TNF-α, suggesting an antitumor effect.
PEV administration also appeared to reduce oxidative stress as evidenced by a decrease in lipid peroxidation.
In addition, PEV confirmed radioprotective effect by radical blocking ability by radiation irradiation.
Immunological responses to PEV administration were evidenced by an increase in number of total white blood cells and T lymphocytes.
Immunotherapy is drawing more and more attention as a treatment for prostate cancer, suggesting that there will be a need for the identification of specific targets for prostate cancer and for more basic research on the genetic aspects of immunotherapy.
Thus, PEV may be of use as a radioprotective supplement during radiotherapy for tumor treatment.
American Psychological Association (APA)
Gu, Yeun-Hwa& Yamashita, Takenori& Yamamoto, Hajime& Matsuo, Tatsuhiko& Washino, Noriyuki& Song, Jin-Ho…[et al.]. 2019. Plant Enzymes Decrease Prostate Cancer Cell Numbers and Increase TNF-α In Vivo: A Possible Role in Immunostimulatory Activity. International Journal of Food Science،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1165409
Modern Language Association (MLA)
Gu, Yeun-Hwa…[et al.]. Plant Enzymes Decrease Prostate Cancer Cell Numbers and Increase TNF-α In Vivo: A Possible Role in Immunostimulatory Activity. International Journal of Food Science No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1165409
American Medical Association (AMA)
Gu, Yeun-Hwa& Yamashita, Takenori& Yamamoto, Hajime& Matsuo, Tatsuhiko& Washino, Noriyuki& Song, Jin-Ho…[et al.]. Plant Enzymes Decrease Prostate Cancer Cell Numbers and Increase TNF-α In Vivo: A Possible Role in Immunostimulatory Activity. International Journal of Food Science. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1165409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165409