Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model
Joint Authors
de la Garza-Ramos, Myriam Angelica
Hernández-Aguas, Jorday
Montiel-Hernández, José Luis
Ruiz-Ramos, Rosa Velia
Escamilla García, Erandi
Guzmán-García, Mario Alberto
Ayón-Haro, Esperanza Raquel
Garza-Elizondo, Mario Alberto
Source
International Journal of Dentistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease.
Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone.
CFA was administered subcutaneously on days 1 and 14.
The arthritis response was monitored for 21 days after day 14 of CFA administration.
IL-1β and IL-6 were determined in serum.
T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen.
Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay.
A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β.
We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA.
A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA.
Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation.
American Psychological Association (APA)
Hernández-Aguas, Jorday& Montiel-Hernández, José Luis& de la Garza-Ramos, Myriam Angelica& Ruiz-Ramos, Rosa Velia& Escamilla García, Erandi& Guzmán-García, Mario Alberto…[et al.]. 2017. Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165487
Modern Language Association (MLA)
Hernández-Aguas, Jorday…[et al.]. Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model. International Journal of Dentistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1165487
American Medical Association (AMA)
Hernández-Aguas, Jorday& Montiel-Hernández, José Luis& de la Garza-Ramos, Myriam Angelica& Ruiz-Ramos, Rosa Velia& Escamilla García, Erandi& Guzmán-García, Mario Alberto…[et al.]. Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1165487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165487