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Arterial Hemodynamics in Prehypertensives
Joint Authors
Ting, Chih-Tai
Chen, Jaw-Wen
Chang, Mau-Song
Yin, Frank Chi-Pong
Source
International Journal of Hypertension
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Compared to age-matched normotensive adults, those with essential hypertension have been shown to have distinct arterial hemodynamic abnormalities consisting of increased peripheral resistance, pulse wave velocity, and wave reflection magnitude as well as decreased wave reflection time and aortic compliance.
These abnormalities are further exacerbated by beta-adrenergic blockade.
To see if there are similar hemodynamic abnormalities that antedate the onset of fixed hypertension, we compared age-matched normotensives with prehypertensives selected from patients undergoing diagnostic cardiac catheterization.
Ascending aortic pressure and flow were measured with a micromanometer and flow velocity sensor in the baseline state and after beta-adrenergic blockade.
In the baseline state the prehypertensive compared to the normotensive group had elevated blood pressure, resistance, left ventricular end-diastolic pressure (LVEDP), and wave reflections.
Beta-adrenergic blockade increased resistance, LVEDP, and wave reflections in both groups.
Some of these findings are the same as those we previously reported in young persons with established, essential hypertension.
The differences in LVEDP and wave reflections, both in the baseline state and after beta-blockade, were still present in subgroups with no differences in blood pressure.
Hence, the elevated wave reflections in prehypertensives do not appear to be directly related to the level of blood pressure.
These results support the notion that the elevated blood pressure in hypertension may represent a later manifestation of an already abnormal vascular system rather than the vascular abnormalities resulting from hypertension.
Consequently, even before blood pressure becomes elevated, early diagnosis and treatment of the vascular abnormalities in prehypertensives may be warranted.
American Psychological Association (APA)
Ting, Chih-Tai& Chen, Jaw-Wen& Chang, Mau-Song& Yin, Frank Chi-Pong. 2019. Arterial Hemodynamics in Prehypertensives. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1166003
Modern Language Association (MLA)
Ting, Chih-Tai…[et al.]. Arterial Hemodynamics in Prehypertensives. International Journal of Hypertension No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1166003
American Medical Association (AMA)
Ting, Chih-Tai& Chen, Jaw-Wen& Chang, Mau-Song& Yin, Frank Chi-Pong. Arterial Hemodynamics in Prehypertensives. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1166003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166003