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GH Responsiveness to Combined GH-Releasing Hormone and Arginine Administration in Obese Patients with Fibromyalgia Syndrome
Joint Authors
Sartorio, Alessandro
Grugni, Graziano
Arreghini, Marco
Capodaglio, Paolo
De Col, Alessandra
Rigamonti, Antonello E.
Agosti, Fiorenza
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Reportedly, fibromyalgia (FM) is frequently associated with reduced IGF-1 levels and GH hyporesponsiveness to different GH stimulation tests.
Since there is a high prevalence of obesity in FM, and obesity itself is characterized by hyposomatotropism, the aim of this study was to assess IGF-1 levels and GH responsiveness in sixteen severely obese women suffering from FM, who, subdivided into two subgroups on the basis of their age-dependent IGF-1 values (> or <−2 SDS), underwent the combined GHRH plus arginine test.
Four out of 16 obese women with FM (25%) had low IGF-1 SDS values, 2 cases of this subgroup (12.5%) failing also to normally respond to the test.
Among patients with normal GH responses, 4 showed a delayed GH peak.
The subgroup with low IGF-1 SDS values had higher BMI than that with normal IGF-1 SDS.
GH peak and area under the curve were not correlated with CRP, ESR, or tender point score, while significant correlations were found with fat-free mass and fat mass.
In conclusion, this study shows the existence of a high prevalence of GH-IGF-1 dysfunction in patients with both FM and obesity, presumably as a consequence of the obese rather than fibromyalgic condition.
American Psychological Association (APA)
Rigamonti, Antonello E.& Grugni, Graziano& Arreghini, Marco& Capodaglio, Paolo& De Col, Alessandra& Agosti, Fiorenza…[et al.]. 2017. GH Responsiveness to Combined GH-Releasing Hormone and Arginine Administration in Obese Patients with Fibromyalgia Syndrome. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166123
Modern Language Association (MLA)
Rigamonti, Antonello E.…[et al.]. GH Responsiveness to Combined GH-Releasing Hormone and Arginine Administration in Obese Patients with Fibromyalgia Syndrome. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166123
American Medical Association (AMA)
Rigamonti, Antonello E.& Grugni, Graziano& Arreghini, Marco& Capodaglio, Paolo& De Col, Alessandra& Agosti, Fiorenza…[et al.]. GH Responsiveness to Combined GH-Releasing Hormone and Arginine Administration in Obese Patients with Fibromyalgia Syndrome. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166123