Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy
Joint Authors
Xu, Lingling
Xie, Cuihua
Guan, Meiping
Li, Linna
Xue, Yaoming
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
33 patients with active, moderate-severe Graves’ ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive).
All patients and 10 controls underwent orbital MRI examination at baseline.
No significant difference was seen in baseline clinical characteristics between the two GO groups.
The values of exophthalmos were higher in both GO groups than in the control and were higher in the responsive group versus the unresponsive group.
Compared to the unresponsive group, the responsive group had a thicker inferior rectus as well as thinner orbital fat.
The inferior rectus/fat ratio was significantly higher in the responsive group versus the unresponsive group.
Multivariate logistic regression analysis showed that the exophthalmos value and inferior rectus/fat ratio were significantly associated with the response to glucocorticoid (GC).
ROC analysis revealed that the cut-off points of the inferior rectus/fat ratio combined with the exophthalmos value to indicate efficacy were 1.42 and 20.78.
For moderate-severe GO patients with CAS > 3, the combined inferior rectus/fat ratio and exophthalmos value in MRI may be a valuable indicator to predict the response to GC therapy.
American Psychological Association (APA)
Xu, Lingling& Li, Linna& Xie, Cuihua& Guan, Meiping& Xue, Yaoming. 2017. Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166135
Modern Language Association (MLA)
Xu, Lingling…[et al.]. Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166135
American Medical Association (AMA)
Xu, Lingling& Li, Linna& Xie, Cuihua& Guan, Meiping& Xue, Yaoming. Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166135