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Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis
Joint Authors
Sezerman, Ugur
Kilic, Elif
Oktem-Okullu, Sinem
Cekic-Kipritci, Zehra
Seymen, Nogayhan
Mansur-Ozen, Nesteren
Gurol, Yesim
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study is to evaluate the association between seven important H.
pylori virulence factors and antibiotic resistance in patients with gastritis.
H.
pylori strains isolated from 33 patients with gastritis were examined.
Antimicrobial susceptibilities were tested by GenoType® HelicoDR (Hain Life Science, Germany) test kit and RT-PCR.
The virulence-factors were determined using conventional PCR.
39% of patients were resistant for clarithromycin and 27% of patients were resistant for fluoroquinolone.
15% of patients were resistant to both clarithromycin and fluoroquinolone.
The H.
pylori vacA m1/s2 genotype was the most frequent allelic combination.
Patients were possessed the vacA s1, m1 (6.1%); s1, m2 (6.1%); s2, m1 (15.1%); and s2, m2 (3.0%) genotypes.
94% of patients with gastritis were positive for H.
pylori napA gene.
Also, there were no dupA gene-positive gastritis patients.
There was no significant correlation between the vacA, cagA, oipA, hpaA, babA, napA, dupA, ureA, ureB virulence genes, clarithromycin, and fluoroquinolone resistance.
Herein, we report that the relationship between the H.
pylori napA gene and gastritis.
Although we found a correlation between H.
pylori virulence factor and clinical outcome, there is a need for further studies to enlighten the relation between H.
pylori virulence genes and antibiotic resistance.
American Psychological Association (APA)
Oktem-Okullu, Sinem& Cekic-Kipritci, Zehra& Kilic, Elif& Seymen, Nogayhan& Mansur-Ozen, Nesteren& Sezerman, Ugur…[et al.]. 2020. Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166783
Modern Language Association (MLA)
Oktem-Okullu, Sinem…[et al.]. Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1166783
American Medical Association (AMA)
Oktem-Okullu, Sinem& Cekic-Kipritci, Zehra& Kilic, Elif& Seymen, Nogayhan& Mansur-Ozen, Nesteren& Sezerman, Ugur…[et al.]. Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166783