Bacterial Diversity in the Intestinal Mucosa of Dysbiosis Diarrhea Mice Treated with Qiweibaizhu Powder
Joint Authors
Yu, Rong
Long, Cheng-Xing
Shao, Hao-Qing
Luo, Cheng-Yu
Tan, Zhou-Jin
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The current research tried to explore the effect of Qiweibaizhu powder (QWBZP) on the bacterial diversity and community structure of the intestinal mucosa of dysbiosis diarrhea mice and provide a scientific basis for the efficacy of QWBZP on antibiotic-induced diarrhea.
A dysbiosis diarrhea mouse model was constructed with broad-spectrum antibiotics through a mixture of cephradine capsules and gentamicin sulfate (23.33 mL·kg-1·d-1).
Intestinal mucosa was collected, and DNA was extracted from each group.
The bacterial characteristics in intestinal mucosa were analyzed by MiSeq sequencing based on the 16S rRNA sequencing platform.
There were no significant differences in alpha diversity indices among the three groups.
The sample distributions in both the normal and QWBZP groups were relatively concentrated, and the distance among individuals was close.
However, an opposite result was obtained in the model group.
Furthermore, the composition and abundance of species were similar between the normal group and the QWBZP group at both the phylum and genus levels.
After treatment with QWBZP, the abundance of Lactobacillus increased, and Proteobacteria decreased, and the Firmicutes/Bacteroidetes ratio decreased to a normal level.
Our results indicate that QWBZP can help repair mucosal bacterial structure and recover mucosal microbiota.
Specifically, QWBZP increased the abundance of Lactobacillus and Bacteroidales S24-7 group norank.
American Psychological Association (APA)
Long, Cheng-Xing& Shao, Hao-Qing& Luo, Cheng-Yu& Yu, Rong& Tan, Zhou-Jin. 2020. Bacterial Diversity in the Intestinal Mucosa of Dysbiosis Diarrhea Mice Treated with Qiweibaizhu Powder. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1167160
Modern Language Association (MLA)
Long, Cheng-Xing…[et al.]. Bacterial Diversity in the Intestinal Mucosa of Dysbiosis Diarrhea Mice Treated with Qiweibaizhu Powder. Gastroenterology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1167160
American Medical Association (AMA)
Long, Cheng-Xing& Shao, Hao-Qing& Luo, Cheng-Yu& Yu, Rong& Tan, Zhou-Jin. Bacterial Diversity in the Intestinal Mucosa of Dysbiosis Diarrhea Mice Treated with Qiweibaizhu Powder. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1167160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167160