Synthesis of Organic Ligands via Reactions of 4-Benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione with N-Nucleophiles
Joint Authors
Kabirifard, Hassan
Hafez Taghva, Pardis
Teimouri, Hossein
Koosheshi, Niloofar
Javadpour, Parastoo
Bagherinejad, Hanieh
Seyfi, Soheila
Hossein Roodbari, Maryam
Golabian, Elaheh
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The reaction of 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione (1) with aminoheteroaryls, lamotrigine, 1,3-diaminoheteroaryls, dapsone, NH2R (hydroxylamine, DL-1-phenylethylamine, and metformin), and 4,4′-bipyridine in THF/H2O (1 : 1) at room temperature led to 3-N-phenylthiocarbamoyl-2-butenamides 2–5, while that with naphthylamines and 1,3-phenylenediamine in ethanol at high temperature led to 5-phenylamino-2,5-dihydrothiophene-2-ones 6–8 as organic ligands in the medium to good yields.
These showed the nucleophilic attacks of N-nucleophiles, except primary aromatic amines, on thioester carboxyl group (C-2) of thiophene-2,3-dione ring 1.
However, the nucleophilic attacks of primary aromatic amines on the carbonyl group (C-3) of thiophene-2,3-dione 1 occurred in the form of substituted thiophenes.
American Psychological Association (APA)
Kabirifard, Hassan& Hafez Taghva, Pardis& Teimouri, Hossein& Koosheshi, Niloofar& Javadpour, Parastoo& Bagherinejad, Hanieh…[et al.]. 2020. Synthesis of Organic Ligands via Reactions of 4-Benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione with N-Nucleophiles. Heteroatom Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1167218
Modern Language Association (MLA)
Kabirifard, Hassan…[et al.]. Synthesis of Organic Ligands via Reactions of 4-Benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione with N-Nucleophiles. Heteroatom Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1167218
American Medical Association (AMA)
Kabirifard, Hassan& Hafez Taghva, Pardis& Teimouri, Hossein& Koosheshi, Niloofar& Javadpour, Parastoo& Bagherinejad, Hanieh…[et al.]. Synthesis of Organic Ligands via Reactions of 4-Benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione with N-Nucleophiles. Heteroatom Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1167218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167218