Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
Joint Authors
Kyriakopoulos, Anthony M.
Nagl, Markus
Baliou, Stella
Zoumpourlis, Vassilis
Source
International Journal of Inflammation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-10
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Clinical Relevance.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays.
These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition.
Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer.
Materials and Methods.
This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals.
Results.
Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition.
Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs.
In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided.
American Psychological Association (APA)
Kyriakopoulos, Anthony M.& Nagl, Markus& Baliou, Stella& Zoumpourlis, Vassilis. 2017. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167509
Modern Language Association (MLA)
Kyriakopoulos, Anthony M.…[et al.]. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. International Journal of Inflammation No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1167509
American Medical Association (AMA)
Kyriakopoulos, Anthony M.& Nagl, Markus& Baliou, Stella& Zoumpourlis, Vassilis. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167509