Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis
Joint Authors
Romero-Sánchez, C.
Bautista-Molano, W.
Parra, V.
De Avila, J.
Rueda, J. C.
Bello-Gualtero, J. M.
Londoño, J.
Valle, R.
Source
International Journal of Rheumatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status.
Objectives.
To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD).
Methods.
102 SpA patients, 29 IBD patients, and 117 HS were included.
Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured.
The patients were assessed to evaluate clinical and gastrointestinal symptoms.
An association analysis was performed using Chi square test and a logistic regression.
Results.
Significant differences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p=0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p<0.001) and abdominal pain (p=0.012) between SpA (54.3%) and IBD (27.5%).
Significant associations were found between BASDAI > 4 and gastrointestinal symptoms (p<0.05) and IgA (p=0.007).
The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; p=0.030).
Conclusions.
Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.
American Psychological Association (APA)
Romero-Sánchez, C.& Bautista-Molano, W.& Parra, V.& De Avila, J.& Rueda, J. C.& Bello-Gualtero, J. M.…[et al.]. 2017. Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis. International Journal of Rheumatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1169375
Modern Language Association (MLA)
Romero-Sánchez, C.…[et al.]. Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis. International Journal of Rheumatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1169375
American Medical Association (AMA)
Romero-Sánchez, C.& Bautista-Molano, W.& Parra, V.& De Avila, J.& Rueda, J. C.& Bello-Gualtero, J. M.…[et al.]. Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis. International Journal of Rheumatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1169375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169375