Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine
Joint Authors
Kuranishi, Fumito
Imaoka, Yuki
Sumi, Yuusuke
Uemae, Yoji
Yasuda-Kurihara, Hiroko
Ishihara, Takeshi
Miyazaki, Tsubasa
Ohno, Tadao
Source
International Journal of Breast Cancer
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
No effective treatment has been developed for bone-metastatic breast cancer.
We found 3 cases with clinical complete response (cCR) of the bone metastasis and longer overall survival of the retrospectively examined cohort treated comprehensively including autologous formalin-fixed tumor vaccine (AFTV).
Patients and Methods.
AFTV was prepared individually for each patient from their own formalin-fixed and paraffin-embedded breast cancer tissues.
Results.
Three patients maintained cCR status of the bone metastasis for 17 months or more.
Rate of cCR for 1 year or more appeared to be 15% (3/20) after comprehensive treatments including AFTV.
The median overall survival time (60.0 months) and the 3- to 8-year survival rates after diagnosis of bone metastasis were greater than those of historical control cohorts in Japan (1988–2002) and in the nationwide population-based cohort study of Denmark (1999–2007).
Conclusion.
Bone-metastatic breast cancer may be curable after comprehensive treatments including AFTV, although larger scale clinical trial is required.
American Psychological Association (APA)
Kuranishi, Fumito& Imaoka, Yuki& Sumi, Yuusuke& Uemae, Yoji& Yasuda-Kurihara, Hiroko& Ishihara, Takeshi…[et al.]. 2018. Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1169453
Modern Language Association (MLA)
Kuranishi, Fumito…[et al.]. Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine. International Journal of Breast Cancer No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1169453
American Medical Association (AMA)
Kuranishi, Fumito& Imaoka, Yuki& Sumi, Yuusuke& Uemae, Yoji& Yasuda-Kurihara, Hiroko& Ishihara, Takeshi…[et al.]. Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1169453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169453