The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
Joint Authors
Wong, Jan H.
Vohra, Nasreen A.
Muzaffar, Mahvish
Johnson, Helen M.
Liles, Darla
Source
International Journal of Breast Cancer
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype.
The impact of locoregional therapy on survival in IBC is controversial.
Methods.
Patients with nonmetastatic IBC between 1988 and 2013 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry.
Results.
We identified 7,304 female patients with nonmetastatic inflammatory breast cancer (IBC) who underwent primary tumor surgery.
Most patients underwent total mastectomy with only 409 (5.6%) undergoing a partial mastectomy.
In addition, 4,559 (62.4%) were also treated with radiation therapy.
The patients who underwent mastectomy had better survival compared to partial mastectomy (49% versus 43%, p = 0.003).
The addition of radiation therapy was also associated with improved 5-year survival (55% versus 40%, p < 0.001).
Multivariate analysis showed that black race HR (1.22, 95% CI 1.18–1.35), ER negative status (HR 1.22, 95% CI 1.16–1.28), and higher grade (HR 1.14, 95% CI 1.07–1.20) were associated with poor outcome.
Cox proportional hazards model showed that total mastectomy (HR 0.75, 95% CI 0.65–0.85) and radiation (HR 0.64, 95% CI 0.61–0.69) were associated with improved survival.
Conclusions.
Optimal locoregional therapy for women with nonmetastatic IBC continues to be mastectomy and radiation therapy.
These data reinforce the prevailing treatment algorithm for nonmetastatic IBC.
American Psychological Association (APA)
Muzaffar, Mahvish& Johnson, Helen M.& Vohra, Nasreen A.& Liles, Darla& Wong, Jan H.. 2018. The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1169458
Modern Language Association (MLA)
Muzaffar, Mahvish…[et al.]. The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study. International Journal of Breast Cancer No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1169458
American Medical Association (AMA)
Muzaffar, Mahvish& Johnson, Helen M.& Vohra, Nasreen A.& Liles, Darla& Wong, Jan H.. The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1169458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169458