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Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients
Joint Authors
Sun, Xiaomin
Zhou, Sirui
He, Xin
Wang, Youfa
Cui, Wei
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To evaluate the relationship between serum 25-hydroxyvitamin (25(OH)D) levels and metabolic risk factor levels in patients with type 2 diabetes mellitus (T2DM) on a sex-specific basis.
Methods.
Our study comprised 507 patients with T2DM (321 men, 186 women; median age, 59 years).
The metabolic risk factors examined included lipoprotein(a), glycated albumin (GA-L), and random blood glucose (RBG); the levels of these parameters were determined enzymatically.
Serum 25(OH)D levels were measured by commercial ELISA kits.
Participants were divided into low and high 25(OH)D groups according to the median 25(OH)D concentration (13.2 ng/mL).
Two-way analysis of covariance and multiple linear regression analysis were performed.
Results.
The median 25(OH)D concentration was 13.9 ng/mL in men and 12.2 ng/mL in women.
25(OH)D levels inversely correlated with levels of three metabolic risk factors in a sex-dependent manner after adjusting for several confounding factors.
These were lipoprotein(a) in men (141.3 ± 137.9 and 195.3 ± 204.8 mg/L in high and low 25(OH)D groups, respectively; P<0.05); GA-L in women (22.2 ± 8.8 vs.
23.3 ± 7.3% in high and low 25(OH)D groups, respectively; P<0.05).
In a subgroup analysis, serum 25(OH)D levels inversely correlated with lipoprotein(a) levels in men (β = −0.185, P=0.002) and RBG levels in women (β = −0.176, P=0.028).
Conclusion.
Higher serum 25(OH)D levels indicate a more favorable lipid profile in men and a more favorable glucose profile in women.
American Psychological Association (APA)
Sun, Xiaomin& Zhou, Sirui& He, Xin& Wang, Youfa& Cui, Wei. 2020. Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170617
Modern Language Association (MLA)
Sun, Xiaomin…[et al.]. Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170617
American Medical Association (AMA)
Sun, Xiaomin& Zhou, Sirui& He, Xin& Wang, Youfa& Cui, Wei. Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170617