Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine
Author
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
A new hydrogen-bonded charge-transfer (HB-CT) complex formed between the donor 2-amino-4-methoxy-6-methylpyrimidine (AMMP) and the π-acceptor 2,5-dihydroxy-p-benzoquinone (DHBQ) was investigated in both solid and solution states.
The investigation was conducted using UV-Vis, CHN, FTIR, 1H NMR, XRD, and TG-DTA analyses.
The molecular composition of the CT complex in MeOH was found to be 1 : 1.
The formation constant (KCT), molecular extinction coefficient (ε), and several other spectroscopic physical parameters were evaluated at different temperatures.
The thermodynamic properties of the CT interaction in MeOH were studied by calculating the enthalpy (ΔH°), entropy (ΔS°), and free energy (ΔG°).
The thermodynamic parameters indicated that van der Waals interactions and hydrogen bonding occur between AMMP and DHBQ in MeOH.
The CHN, FTIR, and TG-DTA measurements confirmed that the solid HB-CT complex forms in a 2 : 1 ratio, i.e., [(AMMP)2(DHBQ)], and exhibits high stability.
Moreover, XRD analysis was used to establish that the mean particle size of the complex is 23 nm.
Finally, the solid HB-CT complex was screened for its antibacterial, antifungal, and antioxidant activities.
It shows good activity against various bacterial and fungal species.
Furthermore, the HB-CT complex exhibits good DPPH scavenging activity.
American Psychological Association (APA)
Alghanmi, Reem M.. 2019. Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1170645
Modern Language Association (MLA)
Alghanmi, Reem M.. Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine. Journal of Chemistry No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1170645
American Medical Association (AMA)
Alghanmi, Reem M.. Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1170645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170645