Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis
Joint Authors
Zantut-Wittmann, Denise E.
Assumpção, Ligia Vera Montalli da
de Melo, Thaís Gomes
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Considering controversial data about the relationship between body size and prognosis of differentiated thyroid cancer (DTC), the current study aimed to assess the influence of body weight, body mass index (BMI), and body surface area (BSA) on DTC.
We conducted a retrospective analysis of patients’ records from the Thyroid Cancer Unit, assessing body size measures, clinical and laboratory prognostic factors, and disease evolution.
337 patients, aged 45.95 ± 13.04 years old, with BMI of 27.87 ± 5.13 kg/m2 and BSA of 1.74 ± 0.18 m2 were enrolled.
After 9.5 ± 6.9 years of follow-up, 87.29% of patients were disease-free and 12.71% had persistent disease; no patient had deceased.
Patients aged <45 years old with extrathyroidal invasion tumor had greater baseline body weight and BSA than those without extrathyroidal invasion (median 79.5 kg versus 67 kg and 1.85 m2 versus 1.74 m2).
Women with poorly differentiated tumor and patients aged ≥45 years old with distant metastasis presented greater weight loss during follow-up compared to patients without such characteristics (median −2 kg versus +1.5 kg and −3 kg versus +1 kg, respectively).
The relationship between body size and DTC evolution was not observed.
In conclusion, higher weight and BSA were associated with a greater chance of extrathyroidal tumor invasion in younger patients.
Specific subgroups of patients with aggressive disease presented higher weight loss.
Young patients with higher BSA should be carefully treated due to possible worse prognosis related to increased incidence of extrathyroid invasion.
Findings related to tumor aggressiveness and weight loss in specific groups deserve further mechanistic studies.
American Psychological Association (APA)
de Melo, Thaís Gomes& Assumpção, Ligia Vera Montalli da& Zantut-Wittmann, Denise E.. 2018. Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171149
Modern Language Association (MLA)
de Melo, Thaís Gomes…[et al.]. Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171149
American Medical Association (AMA)
de Melo, Thaís Gomes& Assumpção, Ligia Vera Montalli da& Zantut-Wittmann, Denise E.. Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171149