Sheehan’s Syndrome Revisited: Underlying Autoimmunity or Hypoperfusion?
Joint Authors
Rodríguez-Guajardo, René
González-González, José Gerardo
Rodríguez-Gutiérrez, René
Borjas-Almaguer, Omar David
Salcido-Montenegro, Alejandro
Elizondo-Plazas, Anasofia
Montes-de-Oca-Luna, Roberto
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sheehan’s syndrome remains a frequent obstetric complication with an uncertain pathophysiology.
We aimed to assess the incidence of hypopituitarism (≥2 hormonal axis impairment) within the first six postchildbirth months and to determine the existence of anti-pituitary antibodies.
From 2015 to 2017, adult pregnant women, who developed moderate to severe postpartum hemorrhage (PPH), were consecutively included in the study.
Pituitary function was assessed 4 and 24 weeks after PPH.
At the end of the study, anti-pituitary antibodies were assessed.
Twenty women completed the study.
Mean age was 26.35 (±5.83) years.
The main etiology for severe PPH was uterine atony (65%) which resulted mostly in hypovolemic shock grades III-IV.
Within the first four weeks after delivery, 95% of patients had at least one hormonal pituitary affected and 60% of the patients fulfilled diagnostic criteria for hypopituitarism.
At the end of the study period, five patients (25%) were diagnosed with hypopituitarism (GH and cortisol axes affected).
Anti-pituitary antibodies were negative in all patients.
At 6 months follow-up, one in every four women with a history of moderate-to-severe PPH was found with asymptomatic nonautoimmune-mediated hypopituitarism.
The role of autoimmunity in Sheehan’s syndrome remains uncertain.
Further studies are needed to improve the remaining knowledge gaps.
American Psychological Association (APA)
González-González, José Gerardo& Borjas-Almaguer, Omar David& Salcido-Montenegro, Alejandro& Rodríguez-Guajardo, René& Elizondo-Plazas, Anasofia& Montes-de-Oca-Luna, Roberto…[et al.]. 2018. Sheehan’s Syndrome Revisited: Underlying Autoimmunity or Hypoperfusion?. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172156
Modern Language Association (MLA)
González-González, José Gerardo…[et al.]. Sheehan’s Syndrome Revisited: Underlying Autoimmunity or Hypoperfusion?. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1172156
American Medical Association (AMA)
González-González, José Gerardo& Borjas-Almaguer, Omar David& Salcido-Montenegro, Alejandro& Rodríguez-Guajardo, René& Elizondo-Plazas, Anasofia& Montes-de-Oca-Luna, Roberto…[et al.]. Sheehan’s Syndrome Revisited: Underlying Autoimmunity or Hypoperfusion?. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172156