The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients
Joint Authors
Yonata, Ade
Ali, Zulkhair
Indrajaya, Taufik
Bahar, Erial
Effendi, Ian
Suhaimi, Novadian
Suprapti, Suprapti
Source
International Journal of Nephrology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications.
Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process.
Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification.
This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia.
Methods.
We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019.
The level of activin A was measured by enzyme-linked immunosorbent assay.
Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging.
Results.
A total of 55 patients with CKD were included in this investigation.
The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm.
A relationship between the serum activin A level and cIMT (r = 0.449; p=0.001) was observed.
During multivariate analysis with linear regression, triglyceride p=0.049, phosphate p=0.005, and activin A p=0.020 serum levels were factors associated with cIMT.
Conclusion.
In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified.
Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.
American Psychological Association (APA)
Yonata, Ade& Ali, Zulkhair& Indrajaya, Taufik& Bahar, Erial& Effendi, Ian& Suhaimi, Novadian…[et al.]. 2020. The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1172820
Modern Language Association (MLA)
Yonata, Ade…[et al.]. The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. International Journal of Nephrology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1172820
American Medical Association (AMA)
Yonata, Ade& Ali, Zulkhair& Indrajaya, Taufik& Bahar, Erial& Effendi, Ian& Suhaimi, Novadian…[et al.]. The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1172820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172820