The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis
Joint Authors
Chen, Jinhu
Xing, Yuling
Zhao, Liying
Ma, Huijuan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The association between Helicobacter pylori infection and glycated hemoglobin A has been confirmed in many studies, but these conclusions are still contradictory and controversial.
Therefore, we conducted a meta-analysis to resolve the problem of inconsistent results in diabetes.
Methods.
A comprehensive search was conducted on related researches published in PubMed, Embase, and China Academic Journal Full-text Database (CNKI) from the inception of each database to April 2019.
Fixed or random effects model was used to pool the weighted mean difference with 95% confidence interval from individual studies.
Subgroup and sensitivity analyses were also performed.
Publication bias was estimated by funnel plot, Egger’s test, and fail-safe numbers.
Results.
35 studies with 4,401 participants with diabetes were included in the meta-analysis.
Glycated hemoglobin A levels were elevated in patients with Helicobacter pylori infection compared with patients without Helicobacter pylori infection (WMD=0.50, 95% CI: 0.28-0.72, p<0.001).
In subgroup analysis by the subtype of diabetes, there was a correlation between Helicobacter pylori infection and elevated glycated hemoglobin A in type 1 diabetes (I2=74%, p<0.001, WMD=0.46, 95% CI: 0.12-0.80), and in type 2 diabetes (I2=90%, p<0.001, WMD=0.59, 95% CI: 0.28-0.90, p<0.001).
In subgroup analysis by the study design, there was a correlation in cross-sectional study (I2=89%, p<0.001, WMD=0.42, 95% CI: 0.16-0.69, p≤0.003) and in case-control study (I2=83%, p<0.001, WMD=0.39, 95% CI: 0.14-0.64, p≤0.003).
By different methods for detecting Helicobacter pylori, there was a correlation in the biopsy group (I2=83%, p<0.001, WMD=0.6, 95% CI: 0.11-1.09, p≤0.03) and in other groups of test methods (I2=87%, p<0.001, WMD=0.37, 95% CI: 0.17-0.56, p<0.001).
Sensitivity analysis showed that our results were reliable, and no evidence of substantial publication bias was detected.
Conclusion.
The meta-analysis might indicate a correlation between Helicobacter pylori infection and glycated hemoglobin A levels in diabetes.
American Psychological Association (APA)
Chen, Jinhu& Xing, Yuling& Zhao, Liying& Ma, Huijuan. 2019. The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172889
Modern Language Association (MLA)
Chen, Jinhu…[et al.]. The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172889
American Medical Association (AMA)
Chen, Jinhu& Xing, Yuling& Zhao, Liying& Ma, Huijuan. The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172889