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ISOdb: A Comprehensive Database of Full-Length Isoforms Generated by Iso-Seq
Joint Authors
Chen, Xiaozhou
Xie, Shang-Qian
Han, Yue
Cao, Tai-Yu
Ji, Kai-Kai
Zhu, Jie
Ling, Peng
Xiao, Chuan-Le
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The accurate landscape of transcript isoforms plays an important role in the understanding of gene function and gene regulation.
However, building complete transcripts is very challenging for short reads generated using next-generation sequencing.
Fortunately, isoform sequencing (Iso-Seq) using single-molecule sequencing technologies, such as PacBio SMRT, provides long reads spanning entire transcript isoforms which do not require assembly.
Therefore, we have developed ISOdb, a comprehensive resource database for hosting and carrying out an in-depth analysis of Iso-Seq datasets and visualising the full-length transcript isoforms.
The current version of ISOdb has collected 93 publicly available Iso-Seq samples from eight species and presents the samples in two levels: (1) sample level, including metainformation, long read distribution, isoform numbers, and alternative splicing (AS) events of each sample; (2) gene level, including the total isoforms, novel isoform number, novel AS number, and isoform visualisation of each gene.
In addition, ISOdb provides a user interface in the website for uploading sample information to facilitate the collection and analysis of researchers’ datasets.
Currently, ISOdb is the first repository that offers comprehensive resources and convenient public access for hosting, analysing, and visualising Iso-Seq data, which is freely available.
American Psychological Association (APA)
Xie, Shang-Qian& Han, Yue& Chen, Xiaozhou& Cao, Tai-Yu& Ji, Kai-Kai& Zhu, Jie…[et al.]. 2018. ISOdb: A Comprehensive Database of Full-Length Isoforms Generated by Iso-Seq. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172912
Modern Language Association (MLA)
Xie, Shang-Qian…[et al.]. ISOdb: A Comprehensive Database of Full-Length Isoforms Generated by Iso-Seq. International Journal of Genomics No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1172912
American Medical Association (AMA)
Xie, Shang-Qian& Han, Yue& Chen, Xiaozhou& Cao, Tai-Yu& Ji, Kai-Kai& Zhu, Jie…[et al.]. ISOdb: A Comprehensive Database of Full-Length Isoforms Generated by Iso-Seq. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172912