Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin
Author
Source
International Journal of Inflammation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation.
The rhizome’s curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers.
Despite the expansive reports of curcucmin’s therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor.
The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications.
Although the polypharmacology of this extract has been considered, in mainstream medicine, to be a drawback, a perspective change reveals a comprehensive and even synergistic shaping of the NF-kB pathway, including transactivation.
Much of the inconsistent research data and unreliable clinical outcomes may be due to a lack of standardization which also pervades research standard samples.
The possibility of other well-known curcumin by-products contributing in the polypharmacology is also discussed.
A new flowchart of crosstalk in transduction pathways that lead to shaping of nuclear NF-kB transactivation is generated and a new calibration or standardization protocol for the extract is proposed which could lead to more consistent data extraction and improved reliability in therapy.
American Psychological Association (APA)
Cavaleri, Franco. 2018. Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1173251
Modern Language Association (MLA)
Cavaleri, Franco. Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. International Journal of Inflammation No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1173251
American Medical Association (AMA)
Cavaleri, Franco. Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1173251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173251