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Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men
Joint Authors
Blumenthal, Jacob B.
Gitterman, Anna
Ryan, Alice S.
Prior, Steven J.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood.
Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL.
Therefore, we examined the effects of 6-month AEX+WL on plasma fetuin-A levels (36–48 hours after the last bout of exercise), aerobic capacity (VO2max), body composition, glucose tolerance, and insulin sensitivity (M) in 16 sedentary, overweight-obese older men (age = 60 ± 2 years, BMI = 31 ± 1 kg/m2) with no history of cardiovascular disease or diabetes.
At baseline, fetuin-A levels correlated directly with adiposity and had a borderline inverse correlation with M.
After AEX+WL, body weight decreased by ~10 kg, while both VO2max and M increased by 16% (P<0.005 for all).
Contrary to our hypothesis, plasma fetuin-A levels increased after AEX+WL (1.16 ± 0.10 g/L versus 1.70 ± 0.19 g/L, P=0.006).
This increase was unrelated to changes in body composition or glucose metabolism, but directly correlated with changes in VO2max (r=0.57, P<0.05).
Thus, in overweight-to-obese older men, AEX+WL appears to increase plasma fetuin-A levels.
Although not associated with improvements in insulin sensitivity, this increase in fetuin-A was related to improvements in aerobic capacity and could be representative of the cardioprotective effects of AEX+WL in older men.
American Psychological Association (APA)
Blumenthal, Jacob B.& Gitterman, Anna& Ryan, Alice S.& Prior, Steven J.. 2017. Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1173811
Modern Language Association (MLA)
Blumenthal, Jacob B.…[et al.]. Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men. Journal of Diabetes Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1173811
American Medical Association (AMA)
Blumenthal, Jacob B.& Gitterman, Anna& Ryan, Alice S.& Prior, Steven J.. Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1173811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173811