The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media
Joint Authors
Surono, Agus
Darmawan, Anton Budhi
Soesatyo, Marsetyawan H. N. E.
Restuti, Ratna Dwi
Source
International Journal of Otolaryngology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Chronic suppurative otitis media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment especially in developing countries.
The role of Mannose-Binding Lectin (MBL), a component of innate immunity, in CSOM has not been studied.
The aim of the study was to examine whether MBL deficiency was more frequently present in cases group of tubotympanic CSOM patients rather than healthy subjects.
Material and Methods.
This was an analytic observational study.
Subjects were enrolled in the Otorhinolaryngology Clinic at Margono Soekarjo Hospital, Purwokerto, Indonesia.
An independent t-test was used to compare the mean of MBL serum concentration between tubotympanic CSOM subjects and control.
Results.
From 36 tubotympanic CSOM patients, there were 8 (22.22%) patients with MBL deficiency (MBL level < 100 ng/ml), while no deficiency was found in the control group.
The mean of MBL level in cases group was 354.88 ng/ml, with the lowest level being 0.001 ng/ml and the highest level 690.24 ng/ml, while in the control group MBL level mean was 376.27 with the lowest level being 188.71 and the highest level 794.54 ng/ml.
Conclusion.
There was no significant difference of MBL serum level between tubotympanic CSOM and control group.
However, the presence of subjects with MBL deficiency in the tubotympanic CSOM group might be considered as playing a role in the tubotympanic CSOM.
American Psychological Association (APA)
Darmawan, Anton Budhi& Soesatyo, Marsetyawan H. N. E.& Restuti, Ratna Dwi& Surono, Agus. 2018. The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. International Journal of Otolaryngology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1173846
Modern Language Association (MLA)
Darmawan, Anton Budhi…[et al.]. The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. International Journal of Otolaryngology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1173846
American Medical Association (AMA)
Darmawan, Anton Budhi& Soesatyo, Marsetyawan H. N. E.& Restuti, Ratna Dwi& Surono, Agus. The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. International Journal of Otolaryngology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1173846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173846