Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria
Joint Authors
John, Kevin
Gunasekaran, Karthik
Sadiq, Mohammad
George, Tina
Francis, Nirmal
Rajadurai, Ebenezer
Sudarsanam, Thambu David
Source
International Journal of Rheumatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis.
We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria.
A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study.
A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women.
The mean age at presentation was 39.3 years (SD±11.6).
The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%).
The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5).
The Kahn criteria and Alarcón-Segovia criteria had the maximum specificity; the Alarcón-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9).
The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively.
American Psychological Association (APA)
John, Kevin& Sadiq, Mohammad& George, Tina& Gunasekaran, Karthik& Francis, Nirmal& Rajadurai, Ebenezer…[et al.]. 2020. Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria. International Journal of Rheumatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1173995
Modern Language Association (MLA)
John, Kevin…[et al.]. Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria. International Journal of Rheumatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1173995
American Medical Association (AMA)
John, Kevin& Sadiq, Mohammad& George, Tina& Gunasekaran, Karthik& Francis, Nirmal& Rajadurai, Ebenezer…[et al.]. Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria. International Journal of Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1173995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173995