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Radical Gastrectomy: Still the Cornerstone of Curative Treatment for Gastric Cancer in the Perioperative Chemotherapy Era—A Single Institute Experience over a Decade
Joint Authors
Kanhere, Harsh
Goel, Raghav
Finlay, Ben
Trochsler, Markus
Maddern, Guy J.
Source
International Journal of Surgical Oncology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Objectives.
Most gastric cancer patients now undergo perioperative chemotherapy (POCT) based on the MAGIC trial results.
POCT consists of neoadjuvant chemotherapy (NACT) as well as postoperative adjuvant chemotherapy.
This study assessed the applicability of perioperative chemotherapy and the impact of radical gastrectomy encompassing a detailed lymph-node resection on outcomes of gastric cancer.
Methods.
Medical and pathology records of all gastric carcinoma resections were reviewed from 2006 onwards.
Pathological details, number of lymph-nodes resected, and proportion of involved nodes, reasons for nonadministration of NACT, complications, recurrence, and survival data were analysed.
Results.
Only twenty-eight (37.8%) out of 74 patients underwent NACT and only nine completed POCT.
NACT was declined due to comorbidities/patient refusal n=24, early stage n=14, and emergency presentation n=8.
Patients receiving NACT were much younger.
Anastomotic leaks, hospital-mortality, lymph-node yield, and proportion of involved lymph-nodes were similar in both groups.
Thirty-two patients died due to recurrence with lymph-node involvement heralding higher recurrence risk and much poorer survival (HR 2.66; p=0.013).
Conclusion.
More than 60% patients with resectable gastric carcinoma did not undergo NACT.
Radical gastrectomy with lymphadenectomy remained the cornerstone of treatment in this period.
American Psychological Association (APA)
Kanhere, Harsh& Goel, Raghav& Finlay, Ben& Trochsler, Markus& Maddern, Guy J.. 2018. Radical Gastrectomy: Still the Cornerstone of Curative Treatment for Gastric Cancer in the Perioperative Chemotherapy Era—A Single Institute Experience over a Decade. International Journal of Surgical Oncology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1175699
Modern Language Association (MLA)
Kanhere, Harsh…[et al.]. Radical Gastrectomy: Still the Cornerstone of Curative Treatment for Gastric Cancer in the Perioperative Chemotherapy Era—A Single Institute Experience over a Decade. International Journal of Surgical Oncology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1175699
American Medical Association (AMA)
Kanhere, Harsh& Goel, Raghav& Finlay, Ben& Trochsler, Markus& Maddern, Guy J.. Radical Gastrectomy: Still the Cornerstone of Curative Treatment for Gastric Cancer in the Perioperative Chemotherapy Era—A Single Institute Experience over a Decade. International Journal of Surgical Oncology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1175699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175699