Study of the Mechanical Environment of Chondrocytes in Articular Cartilage Defects Repaired Area under Cyclic Compressive Loading
Joint Authors
Wei, Wang
Zhang, Chunqiu
Liu, Hai-Ying
Duan, Hang-Tian
Source
Journal of Healthcare Engineering
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
COMSOL finite element software was used to establish a solid-liquid coupling biphasic model of articular cartilage and a microscopic model of chondrocytes, using modeling to take into account the shape and number of chondrocytes in cartilage lacuna in each layer.
The effects of cyclic loading at different frequencies on the micromechanical environment of chondrocytes in different regions of the cartilage were studied.
The results showed that low frequency loading can cause stress concentration of superficial chondrocytes.
Moreover, along with increased frequency, the maximum value of stress response curve of chondrocytes decreased, while the minimum value increased.
When the frequency was greater than 0.2 Hz, the extreme value stress of response curve tended to be constant.
Cyclic loading had a large influence on the distribution of liquid pressure in chondrocytes in the middle and deep layers.
The concentration of fluid pressure changed alternately from intracellular to peripheral in the middle layer.
Both the range of liquid pressure in the upper chondrocytes and the maximum value of liquid pressure in the lower chondrocytes in the same lacunae varied greatly in the deep layer.
At the same loading frequency, the elastic modulus of artificial cartilage had little effect on the mechanical environment of chondrocytes.
American Psychological Association (APA)
Liu, Hai-Ying& Duan, Hang-Tian& Zhang, Chunqiu& Wei, Wang. 2017. Study of the Mechanical Environment of Chondrocytes in Articular Cartilage Defects Repaired Area under Cyclic Compressive Loading. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1180779
Modern Language Association (MLA)
Liu, Hai-Ying…[et al.]. Study of the Mechanical Environment of Chondrocytes in Articular Cartilage Defects Repaired Area under Cyclic Compressive Loading. Journal of Healthcare Engineering No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1180779
American Medical Association (AMA)
Liu, Hai-Ying& Duan, Hang-Tian& Zhang, Chunqiu& Wei, Wang. Study of the Mechanical Environment of Chondrocytes in Articular Cartilage Defects Repaired Area under Cyclic Compressive Loading. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1180779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180779