Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women
Joint Authors
Wassertheil-Smoller, Sylvia
LaCroix, Andrea Z.
Bea, Jennifer W.
Wertheim, Betsy C.
Klimentidis, Yann
Chen, Zhao
Zaslavsky, Oleg
Manini, Todd M.
Womack, Catherine R.
Kroenke, Candyce H.
Thomson, Cynthia A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-19
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging.
We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women’s Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up.
Of those, 2642 were treated for hypertension at baseline.
Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years.
Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001).
There was no association between ACE-I/ARB usage and change in LBM over time.
Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time.
Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.
American Psychological Association (APA)
Bea, Jennifer W.& Wassertheil-Smoller, Sylvia& Wertheim, Betsy C.& Klimentidis, Yann& Chen, Zhao& Zaslavsky, Oleg…[et al.]. 2018. Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women. Journal of Aging Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1180782
Modern Language Association (MLA)
Bea, Jennifer W.…[et al.]. Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women. Journal of Aging Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1180782
American Medical Association (AMA)
Bea, Jennifer W.& Wassertheil-Smoller, Sylvia& Wertheim, Betsy C.& Klimentidis, Yann& Chen, Zhao& Zaslavsky, Oleg…[et al.]. Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women. Journal of Aging Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1180782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180782