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Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles
Joint Authors
Shebl, Rania Ibrahim
Farouk, Faten
Azzazy, Hassan Mohamed El-Said
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Unmodified magnetic nanoparticles (MNPs) lack antibacterial potential.
We investigated MNPs surface modifications that can impart antibacterial activity.
Six MNPs species were prepared and characterized.
Their antibacterial and antibiofilm potentials, surface affinity, and cytotoxicity were evaluated.
Prepared MNPs were functionalized with citric acid, amine group, amino-propyl trimethoxy silane (APTMS), arginine, or oleic acid (OA) to give hydrophilic and hydrophobic MNPs with surface charge ranging from −30 to +30 mV.
Prepared MNPs were spherical in shape with an average size of 6–15 nm.
Hydrophobic (OA-MNPs) and positively charged MNPs (APTMS-MNPs) had significant concentration dependent antibacterial effect.
OA-MNPs showed higher inhibitory potential against S.
aureus and E.
coli (80%) than APTMS-MNPs (70%).
Both particles exhibited surface affinity to S.
aureus and E.
coli.
Different concentrations of OA-MNPs decreased S.
aureus and E.
coli biofilm formation by 50–90%, while APTMS-MNPs reduced it by 30–90%, respectively.
Up to 90% of preformed biofilms of S.
aureus and E.
coli were destroyed by OA-MNPs and APTMS-MNPs.
In conclusion, surface positivity and hydrophobicity enhance antibacterial and antibiofilm properties of MNPs.
American Psychological Association (APA)
Shebl, Rania Ibrahim& Farouk, Faten& Azzazy, Hassan Mohamed El-Said. 2017. Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1182900
Modern Language Association (MLA)
Shebl, Rania Ibrahim…[et al.]. Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles. Journal of Nanomaterials No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1182900
American Medical Association (AMA)
Shebl, Rania Ibrahim& Farouk, Faten& Azzazy, Hassan Mohamed El-Said. Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1182900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182900