Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene
Joint Authors
Li, Ke
Wu, Lijun
Liu, Jianjiang
Lin, Wei
Qi, Qiang
Zhao, Tianlan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We report here the clinical, genetic, and molecular characteristics of type 2 diabetes in a Chinese family.
There are differences in the severity and age of onset in diabetes among these families.
By molecular analysis of the complete mitochondrial genome in this family, we identified the homoplasmic m.15897G>A mutation underwent sequence analysis of whole mitochondrial DNA genome, which localized at conventional position ten of tRNAThr, and distinct sets of mtDNA polymorphisms belonging to haplogroup D4b1.
This mutation has been implicated to be important for tRNA identity and stability.
Using cybrid cell models, the decreased efficiency of mitochondrial tRNAThr levels caused by the m.15897G>A mutation results in respiratory deficiency, protein synthesis and assembly, mitochondrial ATP synthesis, and mitochondrial membrane potential.
These mitochondrial dysfunctions caused an increase in the production of reactive oxygen species in the mutant cell lines.
These data provide a direct evidence that a novel tRNA mutation was associated with T2DM.
Thus, our findings provide a new insight into the understanding of pathophysiology of maternally inherited diabetes.
American Psychological Association (APA)
Li, Ke& Wu, Lijun& Liu, Jianjiang& Lin, Wei& Qi, Qiang& Zhao, Tianlan. 2020. Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1182924
Modern Language Association (MLA)
Li, Ke…[et al.]. Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1182924
American Medical Association (AMA)
Li, Ke& Wu, Lijun& Liu, Jianjiang& Lin, Wei& Qi, Qiang& Zhao, Tianlan. Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1182924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182924