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Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana
Joint Authors
Yeboah, Kwame
Kormla Affrim, Patrick
Agyekum, Jennifer A.
Adjei, Afua B.
Owusu Mensah, Richard N. A.
Adu-Gyamfi, Linda
Doughan, Rita O.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation.
Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes.
We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI).
Method.
In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control.
Large-fibre nerve function was assessed by vibration perception threshold (VPT) using a neurothesiometer.
PSN was defined as the VPT > 97.5th percentile from age- and gender-adjusted models in nondiabetic controls.
Results.
The overall prevalence of PSN was 16.6% in the entire study participants.
Compared to non-PSN participants, PSN patients had higher levels of PWVao (9.5 ± 1.7 versus 8.7 ± 1.2 m/s, p=0.016) and CAVI (8.4 ± 1.3 versus 7.6 ± 1.1, p=0.001).
In multiple regression models, VPT was associated with PWVao (β=0.14, p=0.025) and CAVI (β=0.12, p=0.04).
PSN patients had increased odds of CAVI (OR = 1.51 (1.02–2.4), p=0.043), but not PWVao (OR = 1.25 (0.91–1.71), p=0.173).
Conclusion.
PWVao and CAVI were associated with VPT and PSN in diabetes patients in Ghana.
Patients having PSN have increased odds of CAVI, independent of other conventional risk factors.
American Psychological Association (APA)
Yeboah, Kwame& Agyekum, Jennifer A.& Owusu Mensah, Richard N. A.& Kormla Affrim, Patrick& Adu-Gyamfi, Linda& Doughan, Rita O.…[et al.]. 2018. Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183351
Modern Language Association (MLA)
Yeboah, Kwame…[et al.]. Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183351
American Medical Association (AMA)
Yeboah, Kwame& Agyekum, Jennifer A.& Owusu Mensah, Richard N. A.& Kormla Affrim, Patrick& Adu-Gyamfi, Linda& Doughan, Rita O.…[et al.]. Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183351