The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials
Joint Authors
Tong, Nanwei
Liu, Yuqi
Li, Juan
Ma, Jinfang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Intensive glucose therapy can protect the retina of individuals with diabetes, but it is unknown if it provides the same protection to patients with different severity of diabetic retinopathy (DR).
We finally included DR-related studies involving intensive glucose control with large sample size and long follow-up time, including five large and high-quality randomized clinical trials (RCTs): DCCT, UKPDS, ACCORD, AdRem, and VADT.
With DCCT as a reference, we supposed a DR severity threshold that is verified by other RCTs then.
We found that individuals who have DR lesions that are equivalent to or less severe than moderate NPDR achieve benefits for the retina by intensive glycemic control.
However, these are realized only if the HbA1c in type 1 or type 2 diabetic patients is reduced at least by 0.8% versus the control group or it is reduced to <7% and >3 years of intensive glucose control is required.
If the severity of DR lesions is worse than moderate NPDR, intensive glycemic control may not bring benefits.
American Psychological Association (APA)
Liu, Yuqi& Li, Juan& Ma, Jinfang& Tong, Nanwei. 2020. The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183470
Modern Language Association (MLA)
Liu, Yuqi…[et al.]. The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183470
American Medical Association (AMA)
Liu, Yuqi& Li, Juan& Ma, Jinfang& Tong, Nanwei. The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183470