Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs
Joint Authors
Martins, Joilson O.
Tessaro, Fernando H. G.
Nunes, Fernanda P. B.
Ferreira, Sabrina S.
Casagrande, Felipe Beccaria
Romera, Lavínia Maria Dal’Mas
dos Santos, Suelen Silvana
de Souza, Paula Regina Knox
Almeida, Sandro Rogério
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients.
We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis Paracoccidioides brasiliensis (Pb) model.
Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments.
After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs.
In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups.
Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals.
The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection.
American Psychological Association (APA)
Casagrande, Felipe Beccaria& Ferreira, Sabrina S.& Nunes, Fernanda P. B.& Romera, Lavínia Maria Dal’Mas& dos Santos, Suelen Silvana& Tessaro, Fernando H. G.…[et al.]. 2018. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
Modern Language Association (MLA)
Casagrande, Felipe Beccaria…[et al.]. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
American Medical Association (AMA)
Casagrande, Felipe Beccaria& Ferreira, Sabrina S.& Nunes, Fernanda P. B.& Romera, Lavínia Maria Dal’Mas& dos Santos, Suelen Silvana& Tessaro, Fernando H. G.…[et al.]. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183761