Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications
Joint Authors
Dubey, Navneet Kumar
Wei, Hong-Jian
Peng, Boe-Yu
Deng, Win-Ping
Mishra, Viraj Krishna
Tsai, Feng-Chou
Dubey, Rajni
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously.
Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms.
Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications.
These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled.
Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications.
Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors.
Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential.
Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications.
Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.
American Psychological Association (APA)
Peng, Boe-Yu& Dubey, Navneet Kumar& Mishra, Viraj Krishna& Tsai, Feng-Chou& Dubey, Rajni& Deng, Win-Ping…[et al.]. 2018. Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1183901
Modern Language Association (MLA)
Peng, Boe-Yu…[et al.]. Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications. Journal of Diabetes Research No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1183901
American Medical Association (AMA)
Peng, Boe-Yu& Dubey, Navneet Kumar& Mishra, Viraj Krishna& Tsai, Feng-Chou& Dubey, Rajni& Deng, Win-Ping…[et al.]. Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1183901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183901