Antiglycemic Effect of Water Extractable Arabinoxylan from Wheat Aleurone and Bran
Joint Authors
Malunga, Lovemore Nkhata
Beta, Trust
Izydorczyk, Marta
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The studies on the effects of arabinoxylan (AX) polysaccharides on postprandial glucose response have resulted in contrasting results owing to the diversity in AX structures.
Four water extractable AX (WEAX) extracts obtained from wheat aleurone and bran were used to investigate (a) the effect of AX on activities of α-amylase and α-glucosidase, (b) influence of AX chemical composition on their inhibition potency, and (c) kinetics of enzyme inhibition.
α-Amylase activity was not significantly affected by the presence WEAX fractions regardless of type or concentration.
WEAX inhibited α-glucosidase activity only when maltose was used as a substrate but not sucrose.
The IC50 values of WEAX (4.88±0.3–10.14±0.5 mg/mL) were highly correlated to ferulic acid content (R=-0.89), arabinose to xylose ratio (R=-0.67), and relative proportions of xylose being unsubstituted (R=0.69), disubstituted (R=-0.63), and monosubstituted (R=-0.76).
The Lineweaver–Burk plot suggested an uncompetitive enzyme inhibition mode.
Thus, our results suggest that antiglycemic properties of WEAX may be derived from direct inhibition of α-glucosidase activity.
American Psychological Association (APA)
Malunga, Lovemore Nkhata& Izydorczyk, Marta& Beta, Trust. 2017. Antiglycemic Effect of Water Extractable Arabinoxylan from Wheat Aleurone and Bran. Journal of Nutrition and Metabolism،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1183972
Modern Language Association (MLA)
Malunga, Lovemore Nkhata…[et al.]. Antiglycemic Effect of Water Extractable Arabinoxylan from Wheat Aleurone and Bran. Journal of Nutrition and Metabolism No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1183972
American Medical Association (AMA)
Malunga, Lovemore Nkhata& Izydorczyk, Marta& Beta, Trust. Antiglycemic Effect of Water Extractable Arabinoxylan from Wheat Aleurone and Bran. Journal of Nutrition and Metabolism. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1183972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183972