Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems
Joint Authors
Torres, Carlos
Mouhid, Lamia
Corzo-Martínez, Marta
Vázquez, Luis
Ramírez de Molina, Ana
Reglero, Guillermo
Fornari, Tiziana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-34, 34 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-07
Country of Publication
Egypt
No. of Pages
34
Main Subjects
Abstract EN
Cancer is among the leading causes of morbidity and mortality worldwide.
Many of the chemotherapeutic agents used in cancer treatment exhibit cell toxicity and display teratogenic effect on nontumor cells.
Therefore, the search for alternative compounds which are effective against tumor cells but reduce toxicity against nontumor ones is of great importance in the progress or development of cancer treatments.
In this sense, scientific knowledge about relevant aspects of nutrition intimately involved in the development and progression of cancer progresses rapidly.
Phytochemicals, considered as bioactive ingredients present in plant products, have shown promising effects as potential therapeutic/preventive agents on cancer in several in vitro and in vivo assays.
However, despite their bioactive properties, phytochemicals are still not commonly used in clinical practice due to several reasons, mainly attributed to their poor bioavailability.
In this sense, new formulation strategies are proposed as carriers to improve their bioefficacy, highlighting the use of lipid-based delivery systems.
Here, we review the potential antitumoral activity of the bioactive compounds derived from plants and the current studies carried out in animal and human models.
Furthermore, their association with lipids as a formulation strategy to enhance their efficacy in vivo is also reported.
The development of high effective bioactive supplements for cancer treatment based on the improvement of their bioavailability goes through this association.
American Psychological Association (APA)
Mouhid, Lamia& Corzo-Martínez, Marta& Torres, Carlos& Vázquez, Luis& Reglero, Guillermo& Fornari, Tiziana…[et al.]. 2017. Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems. Journal of Oncology،Vol. 2017, no. 2017, pp.1-34.
https://search.emarefa.net/detail/BIM-1184207
Modern Language Association (MLA)
Mouhid, Lamia…[et al.]. Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems. Journal of Oncology No. 2017 (2017), pp.1-34.
https://search.emarefa.net/detail/BIM-1184207
American Medical Association (AMA)
Mouhid, Lamia& Corzo-Martínez, Marta& Torres, Carlos& Vázquez, Luis& Reglero, Guillermo& Fornari, Tiziana…[et al.]. Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems. Journal of Oncology. 2017. Vol. 2017, no. 2017, pp.1-34.
https://search.emarefa.net/detail/BIM-1184207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184207