The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis
Joint Authors
Sun, Xinghuai
Li, Shengjie
Cao, Wenjun
Tang, Binghua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Purpose.
To systematically evaluate the associations between oxidative stress status and different types of glaucoma.
Design.
Systematic review and meta-analysis.
Methods.
We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016.
A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs).
A funnel plot analysis and Egger’s test were performed to assess potential publication bias.
Main outcome measures.
Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma).
Results.
Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L (p<0.0001, 95% CI = −0.668 to −0.492).
The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL (p<0.0001, 95% CI = 14.579–21.298), 12.441 U/mL (p<0.0001, 95% CI = 10.423–14.459), and 1.229 fmol/mL (p=0.042, 95% CI = 0.043–2.414), respectively.
Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L (p<0.0001, 95% CI = −0.393 to −0.132).
However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group.
Conclusions.
This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.
American Psychological Association (APA)
Tang, Binghua& Li, Shengjie& Cao, Wenjun& Sun, Xinghuai. 2019. The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1185138
Modern Language Association (MLA)
Tang, Binghua…[et al.]. The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis. Journal of Ophthalmology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1185138
American Medical Association (AMA)
Tang, Binghua& Li, Shengjie& Cao, Wenjun& Sun, Xinghuai. The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1185138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185138