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Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis
Joint Authors
Tan, Qianglai
Xu, Feng
Xu, Hengyi
Qiu, Liang
Tao, Xueying
Wei, Hua
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-27
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Increasing evidence suggests that Enterococcus faecalis strains can pass through placental barriers and cause adverse outcomes during pregnancy.
However, the underlying molecular mechanism of the interaction between E.
faecalis and the host placental barrier has yet to be fully elucidated.
In this study, we have used DNA microarray analysis to investigate the response of human placental trophoblast-like BeWo cells to infection with E.
faecalis OG1RF.
These results indicate that a total of 2191 genes in BeWo cells are differentially expressed in the presence of E.
faecalis OG1RF, with 1357 genes being upregulated and 834 genes being downregulated.
These differentially expressed genes (DEGs) are involved in apoptosis, stress and stimulus response, placental and embryonic development, immune response, and cell adhesion.
Therefore, these results provide information on the molecular mechanisms that E.
faecalis invasion can trigger to cause adverse pregnancy outcomes.
American Psychological Association (APA)
Tan, Qianglai& Xu, Feng& Xu, Hengyi& Qiu, Liang& Tao, Xueying& Wei, Hua. 2018. Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis. Journal of Food Quality،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1185309
Modern Language Association (MLA)
Tan, Qianglai…[et al.]. Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis. Journal of Food Quality No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1185309
American Medical Association (AMA)
Tan, Qianglai& Xu, Feng& Xu, Hengyi& Qiu, Liang& Tao, Xueying& Wei, Hua. Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis. Journal of Food Quality. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1185309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185309