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Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model
Joint Authors
Nakanishi, Chiaki
Mori, Masayuki
Yoshida, Shohei
Yokawa, Junichiro
Sakata, Kenji
Murai, Kota
Okada, Hirofumi
Shimojima, Masaya
Yoshioka, Kazuaki
Takuwa, Yoh
Yamagishi, Masakazu
Kawashiri, Masaaki
Hayashi, Kenshi
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
We evaluated the effect of the different carrier systems on early vascular response through histological analysis and scanning electron microscopy using a porcine model.
Background.
Although Synergy™ and Promus PREMIER™ share an identical stent material and drug elution (everolimus), they use different drug carrier systems: biodegradable abluminal coating polymer or durable conformal coating polymer, respectively.
However, data regarding the impact of the different coating systems on vessel healing are currently limited.
Methods.
Twelve Synergy™ and Promus PREMIER™ were implanted in 12 swine.
Histopathological analysis of the stented segments was performed on the 2nd and 14th days after implantation.
Morphometric analysis of the inflammation and intimal fibrin content was also performed.
Results.
On the 2nd day, neointimal thickness, percentage of neointimal area, and inflammatory and intimal fibrin content scores were not significantly different between the two groups.
On the 14th day, the inflammatory and intimal fibrin content scores were significantly lower in Synergy™ versus those observed in Promus PREMIER™.
In Synergy™, smooth muscle cells were found and the neointimal layers were smooth.
In contrast, inflammatory cells were observed surrounding the struts of Promus PREMIER™.
Conclusions.
These results demonstrate that termination of reactive inflammation is accelerated after abluminal coating stent versus implantation of conformal coating stent.
American Psychological Association (APA)
Mori, Masayuki& Sakata, Kenji& Yokawa, Junichiro& Nakanishi, Chiaki& Murai, Kota& Okada, Hirofumi…[et al.]. 2020. Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187758
Modern Language Association (MLA)
Mori, Masayuki…[et al.]. Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Journal of Interventional Cardiology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187758
American Medical Association (AMA)
Mori, Masayuki& Sakata, Kenji& Yokawa, Junichiro& Nakanishi, Chiaki& Murai, Kota& Okada, Hirofumi…[et al.]. Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187758