Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats
Joint Authors
Yang, Suh-Ching
Chen, Ya-Ling
Chien, Yi-Wen
Peng, Hsiang-Chi
Chuang, Hsiao-Li
Wang, Hsiao-Yun
Pai, Man-Hui
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sixty male Wistar rats were fed a control or an ethanol-containing diet in groups C or E.
The fat compositions were adjusted with 25% or 57% fish oil substituted for olive oil in groups CF25, CF57, EF25, and EF57.
Hepatic thiobarbituric acid-reactive substance (TBARS) levels, cytochrome P450 2E1 protein expression, and tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-10 levels, as well as intracellular adhesion molecule (ICAM)-1 levels were significantly elevated, whereas plasma adiponectin level was significantly reduced in group E (p<0.05).
Hepatic histopathological scores of fatty change and inflammation, in group E were significantly higher than those of group C (p<0.05).
Hepatic TBARS, plasma ICAM-1, and hepatic TNF-α, IL-1β, and IL-10 levels were significantly lower, and plasma adiponectin levels were significantly higher in groups EF25 and EF57 than those in group E (p<0.05).
The immunoreactive area of the intestinal tight junction protein, ZO-1, showed no change between groups C and E.
Only group CF57 displayed a significantly higher ZO-1 immunoreactive area compared to group C (p=0.0415).
25% or 57% fish oil substituted for dietary olive oil could prevent ethanol-induced liver damage in rats, but the mechanism might not be related to intestinal tight junction ZO-1 expression.
American Psychological Association (APA)
Chien, Yi-Wen& Peng, Hsiang-Chi& Chen, Ya-Ling& Pai, Man-Hui& Wang, Hsiao-Yun& Chuang, Hsiao-Li…[et al.]. 2017. Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188498
Modern Language Association (MLA)
Chien, Yi-Wen…[et al.]. Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188498
American Medical Association (AMA)
Chien, Yi-Wen& Peng, Hsiang-Chi& Chen, Ya-Ling& Pai, Man-Hui& Wang, Hsiao-Yun& Chuang, Hsiao-Li…[et al.]. Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188498