Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas
Joint Authors
Tian, Yixin
Ke, Yi-Quan
Ma, Yanxia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glioma is the most common and deadly tumor in central nervous system.
According to previous studies, long noncoding RNAs (lncRNA) and transcription factors were significant factors of gliomas progression by regulating gliomas immune microenvironment.
In our study, we built two independent cohorts from CGGA and TCGA.
And we extracted 253 immune-related lncRNA correlated with prognosis.
After LASSO analysis and multivariate Cox regression analysis, 8 immune-related lncRNA were used to construct classifier.
The effectiveness of classifier was confirmed in both CGGA (AUC = 0.869) and TCGA (AUC = 0.902) cohorts.
The correlation between transcription factors and immune-related lncRNA was calculated by WCGNA.
Eventually, we built a network between 8 lncRNA and transcription factors.
The function of core immune-related lncRNA in gliomas immune microenvironment was also investigated by CIBERTSORT.
Our research provided a strong classifier of immune-related lncRNA to predict gliomas patient outcome.
We also found the correlation between core immune-related lncRNA and transcription factors.
These results may stimulate new strategy of immunotherapy in gliomas patients.
American Psychological Association (APA)
Tian, Yixin& Ke, Yi-Quan& Ma, Yanxia. 2020. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
Modern Language Association (MLA)
Tian, Yixin…[et al.]. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
American Medical Association (AMA)
Tian, Yixin& Ke, Yi-Quan& Ma, Yanxia. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188871