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Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas
المؤلفون المشاركون
Tian, Yixin
Ke, Yi-Quan
Ma, Yanxia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Glioma is the most common and deadly tumor in central nervous system.
According to previous studies, long noncoding RNAs (lncRNA) and transcription factors were significant factors of gliomas progression by regulating gliomas immune microenvironment.
In our study, we built two independent cohorts from CGGA and TCGA.
And we extracted 253 immune-related lncRNA correlated with prognosis.
After LASSO analysis and multivariate Cox regression analysis, 8 immune-related lncRNA were used to construct classifier.
The effectiveness of classifier was confirmed in both CGGA (AUC = 0.869) and TCGA (AUC = 0.902) cohorts.
The correlation between transcription factors and immune-related lncRNA was calculated by WCGNA.
Eventually, we built a network between 8 lncRNA and transcription factors.
The function of core immune-related lncRNA in gliomas immune microenvironment was also investigated by CIBERTSORT.
Our research provided a strong classifier of immune-related lncRNA to predict gliomas patient outcome.
We also found the correlation between core immune-related lncRNA and transcription factors.
These results may stimulate new strategy of immunotherapy in gliomas patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Yixin& Ke, Yi-Quan& Ma, Yanxia. 2020. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Yixin…[et al.]. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Yixin& Ke, Yi-Quan& Ma, Yanxia. Immune-Related lncRNA Correlated with Transcription Factors Provide Strong Prognostic Prediction in Gliomas. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188871
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188871
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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