The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target
Joint Authors
Argenziano, Monica
Toffoli, Giuseppe
Baboci, Lorena
Capolla, Sara
Di Cintio, Federica
Colombo, Federico
Mauro, Prisca
Dal Bo, Michele
Macor, Paolo
Cavalli, Roberta
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The development of nanostructures for therapeutic purpose is rapidly growing, following the results obtained in vivo in animal models and in the clinical trials.
Unfortunately, the potential therapeutic efficacy is not completely exploited, yet.
This is mainly due to the fast clearance of the nanostructures in the body.
Nanoparticles and the liver have a unique interaction because the liver represents one of the major barriers for drug delivery.
This interaction becomes even more relevant and complex when the drug delivery strategies employing nanostructures are proposed for the therapy of liver diseases, such as hepatocellular carcinoma (HCC).
In this case, the selective delivery of therapeutic nanoparticles to the tumor microenvironment collides with the tendency of nanostructures to be quickly eliminated by the organ.
The design of a new therapeutic approach based on nanoparticles to treat HCC has to particularly take into consideration passive and active mechanisms to avoid or delay liver elimination and to specifically address cancer cells or the cancer microenvironment.
This review will analyze the different aspects concerning the dual role of the liver, both as an organ carrying out a clearance activity for the nanostructures and as target for therapeutic strategies for HCC treatment.
American Psychological Association (APA)
Baboci, Lorena& Capolla, Sara& Di Cintio, Federica& Colombo, Federico& Mauro, Prisca& Dal Bo, Michele…[et al.]. 2020. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
Modern Language Association (MLA)
Baboci, Lorena…[et al.]. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
American Medical Association (AMA)
Baboci, Lorena& Capolla, Sara& Di Cintio, Federica& Colombo, Federico& Mauro, Prisca& Dal Bo, Michele…[et al.]. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188955