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Correlation between Urine N-Terminal Telopeptide and Fourier Transform Infrared Spectroscopy Parameters: A Preliminary Study
Joint Authors
Girardi, Federico P.
Hughes, Alexander P.
Okano, Ichiro
Salzmann, Stephan N.
Ortiz Miller, Courtney
Rentenberger, Colleen
Schadler, Paul
Sax, Oliver C.
Shue, Jennifer
Cammisa, Frank P.
Sama, Andrew A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
N-terminal telopeptide (NTX) is a bone resorption marker that is commonly referenced in clinical practice.
Bone remodeling is also associated with changes in mineral components.
Fourier transform infrared spectroscopy (FTIR) is utilized in the assessment of bone material properties and some parameters are reported to have associations with bone remodeling.
The aim of this cross-sectional study is to investigate the relationship between uNTX levels and FTIR parameters, utilizing prospectively collected study data for patients who underwent lumbar fusion surgery.
Bone specimens were taken from iliac crest (IC) and vertebrae (V).
Cortical (C) and trabecular (T) bones were separately analyzed.
22 patients (mean age 60.0 years (35.9–73.3), male : female 9 : 13) were included in the final analysis.
Women showed significantly higher uNTX levels (male : female, median [range] 21.0 [11.0–39.0] : 36.0 [15.0–74.0] nM·BCE/mM, p=0.033).
Among women, a significant positive correlation was observed between uNTX and mineral-to-matrix ratio in IC-C.
Among men, uNTX demonstrated significant negative correlation with collagen crosslinks (XLR: ratio of mature to immature collagen crosslinks) in IC-C, V-T, and V-C.
In addition, uNTX was positively correlated with acid phosphate substitution (HPO4, a parameter of new bone formation) in IC-C, IC-T, and V-C.
After age adjustment, HPO4 in IC-T and V-C among men showed significant positive associations with uNTX (IC-T: p=0.018, R2 = 0.544; V-C: p=0.007, R2 = 0.672).
We found associations between FTIR parameters and uNTX in men, but not in women.
The correlations between uNTX and FTIR parameters in men might suggest a better balance of bone breakdown (uNTX) and new bone formation (FTIR parameters: XLR, HPO4) than in women.
American Psychological Association (APA)
Okano, Ichiro& Salzmann, Stephan N.& Ortiz Miller, Courtney& Rentenberger, Colleen& Schadler, Paul& Sax, Oliver C.…[et al.]. 2020. Correlation between Urine N-Terminal Telopeptide and Fourier Transform Infrared Spectroscopy Parameters: A Preliminary Study. Journal of Osteoporosis،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189936
Modern Language Association (MLA)
Okano, Ichiro…[et al.]. Correlation between Urine N-Terminal Telopeptide and Fourier Transform Infrared Spectroscopy Parameters: A Preliminary Study. Journal of Osteoporosis No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189936
American Medical Association (AMA)
Okano, Ichiro& Salzmann, Stephan N.& Ortiz Miller, Courtney& Rentenberger, Colleen& Schadler, Paul& Sax, Oliver C.…[et al.]. Correlation between Urine N-Terminal Telopeptide and Fourier Transform Infrared Spectroscopy Parameters: A Preliminary Study. Journal of Osteoporosis. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189936