IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response
Joint Authors
Zhu, Junfeng
Lu, Changlong
Xu, Ying
Zhao, Jian
Li, Xue
Meng, Xinrui
Wang, Tian-qi
Zou, Ben-yao
Zhao, Peng-yan
Liu, Qi
Zheng, Fang-liang
Liu, Hong-sheng
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis.
Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis.
So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice.
Methods.
IL-33 was administered by intraperitoneal injection to mice with DSS-induced chronic colitis.
Clinical symptoms, colon length, and histological changes were determined.
The production of cytokines was measured by ELISA.
The T and B cell subsets were measured by flow cytometry.
The expression of mRNA of transcription factors was measured by quantitative real-time PCR.
Results.
We show that IL-33 treatment increases both Breg and Treg responses in the MLN of mice with DSS-induced chronic colitis.
Moreover, IL-33 treatment also decreases Th17 cell response in the MLN of mice with DSS-induced chronic colitis.
Conclusion.
Our data provide clear evidence that IL-33 plays a protective role in DSS-induced chronic colitis, which is closely related to increasing Breg and Treg responses in the MLN of mice as well as suppressing Th17 cell responses.
American Psychological Association (APA)
Zhu, Junfeng& Xu, Ying& Zhao, Jian& Li, Xue& Meng, Xinrui& Wang, Tian-qi…[et al.]. 2018. IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191696
Modern Language Association (MLA)
Zhu, Junfeng…[et al.]. IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1191696
American Medical Association (AMA)
Zhu, Junfeng& Xu, Ying& Zhao, Jian& Li, Xue& Meng, Xinrui& Wang, Tian-qi…[et al.]. IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191696