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Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer
Joint Authors
López-Santiago, Rubén
Vela-Ojeda, Jorge
Moreno-Lafont, Martha
Vieyra-Lobato, Martha R.
Montiel-Cervantes, Laura
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Gershon and Kondo described CD8+ Treg lymphocytes as the first ones with regulating activity due to their tolerance ability to foreign antigens and their capacity to inhibit the proliferation of other lymphocytes.
Regardless, CD8+ Treg lymphocytes have not been fully described—unlike CD4+ Treg lymphocytes—because of their low numbers in blood and the lack of specific and accurate population markers.
Still, these lymphocytes have been studied for the past 30 years, even after finding difficulties during investigations.
As a result, studies have identified markers that define their subpopulations.
This review is focused on the expression of cell membrane markers as CD25, CD122, CD103, CTLA-4, CD39, CD73, LAG-3, and FasL as well as soluble molecules such as FoxP3, IFN-γ, IL-10, TGF-β, IL-34, and IL-35, in addition to the lack of expression of cell activation markers such as CD28, CD127 CD45RC, and CD49d.
This work also underlines the importance of identifying some of these markers in infections with several pathogens, autoimmunity, cancer, and graft-versus-host disease as a strategy in their prevention, monitoring, and cure.
American Psychological Association (APA)
Vieyra-Lobato, Martha R.& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& López-Santiago, Rubén& Moreno-Lafont, Martha. 2018. Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1192197
Modern Language Association (MLA)
Vieyra-Lobato, Martha R.…[et al.]. Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer. Journal of Immunology Research No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1192197
American Medical Association (AMA)
Vieyra-Lobato, Martha R.& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& López-Santiago, Rubén& Moreno-Lafont, Martha. Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1192197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192197