The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China
Joint Authors
Hu, Sindy
Cheng, Bo
Yang, Shang-Chen
Zhang, Sheng-Zheng
Huang, Jin-wen
Zhang, Jing
Ji, Chao
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease.
However, there are only few epidemiologic studies of SJS/TEN from China.
To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period.
There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN.
The most common offending drugs were antibiotics (29.5%) and anticonvulsants (24.1%).
Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%).
Chinese patent medicines accounted for 5.4%.
There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone.
Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance.
In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China.
Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.
American Psychological Association (APA)
Yang, Shang-Chen& Hu, Sindy& Zhang, Sheng-Zheng& Huang, Jin-wen& Zhang, Jing& Ji, Chao…[et al.]. 2018. The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192301
Modern Language Association (MLA)
Yang, Shang-Chen…[et al.]. The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192301
American Medical Association (AMA)
Yang, Shang-Chen& Hu, Sindy& Zhang, Sheng-Zheng& Huang, Jin-wen& Zhang, Jing& Ji, Chao…[et al.]. The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192301