Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke

Joint Authors

Boyd, Lara A.
Peters, Sue
Hayward, Kathryn S.
Mang, Cameron S.
Neva, Jason L.
Wadden, Katie P.
Ferris, Jennifer K.

Source

Neural Plasticity

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-11-16

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology
Medicine

Abstract EN

Background.

Severity of arm impairment alone does not explain motor outcomes in people with severe impairment post stroke.

Objective.

Define the contribution of brain biomarkers to upper limb motor outcomes in people with severe arm impairment post stroke.

Methods.

Paretic arm impairment (Fugl-Meyer upper limb, FM-UL) and function (Wolf Motor Function Test rate, WMFT-rate) were measured in 15 individuals with severe (FM-UL ≤ 30/66) and 14 with mild–moderate (FM-UL > 40/66) impairment.

Transcranial magnetic stimulation and diffusion weight imaging indexed structure and function of the corticospinal tract and corpus callosum.

Separate models of the relationship between possible biomarkers and motor outcomes at a single chronic (≥6 months) time point post stroke were performed.

Results.

Age (ΔR20.365, p=0.017) and ipsilesional-transcallosal inhibition (ΔR20.182, p=0.048) explained a 54.7% (p=0.009) variance in paretic WMFT-rate.

Prefrontal corpus callous fractional anisotropy (PF-CC FA) alone explained 49.3% (p=0.007) variance in FM-UL outcome.

The same models did not explain significant variance in mild–moderate stroke.

In the severe group, k-means cluster analysis of PF-CC FA distinguished two subgroups, separated by a clinically meaningful and significant difference in motor impairment (p=0.049) and function (p=0.006) outcomes.

Conclusion.

Corpus callosum function and structure were identified as possible biomarkers of motor outcome in people with chronic and severe arm impairment.

American Psychological Association (APA)

Hayward, Kathryn S.& Neva, Jason L.& Mang, Cameron S.& Peters, Sue& Wadden, Katie P.& Ferris, Jennifer K.…[et al.]. 2017. Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193005

Modern Language Association (MLA)

Hayward, Kathryn S.…[et al.]. Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193005

American Medical Association (AMA)

Hayward, Kathryn S.& Neva, Jason L.& Mang, Cameron S.& Peters, Sue& Wadden, Katie P.& Ferris, Jennifer K.…[et al.]. Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193005

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193005