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Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation
Joint Authors
Xia, Shuang
Song, TianBin
Che, Jing
Li, Qiang
Chai, Chao
Zheng, Meizhu
Shen, Wen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Early hearing deprivation could affect the development of auditory, language, and vision ability.
Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development.
Twenty-three infants with congenital severe sensorineural hearing loss (CSSHL) and 17 age and sex matched normal hearing subjects were recruited.
The amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) of the auditory, language, and vision related brain areas were compared between deaf infants and normal subjects.
Compared with normal hearing subjects, decreased ALFF and ReHo were observed in auditory and language-related cortex.
Increased ALFF and ReHo were observed in vision related cortex, which suggest that hearing and language function were impaired and vision function was enhanced due to the loss of hearing.
ALFF of left Brodmann area 45 (BA45) was negatively correlated with deaf duration in infants with CSSHL.
ALFF of right BA39 was positively correlated with deaf duration in infants with CSSHL.
In conclusion, ALFF and ReHo can reflect the abnormal brain function in language, auditory, and visual information processing in infants with CSSHL.
This demonstrates that the development of auditory, language, and vision processing function has been affected by congenital severe sensorineural hearing loss before 4 years of age.
American Psychological Association (APA)
Xia, Shuang& Song, TianBin& Che, Jing& Li, Qiang& Chai, Chao& Zheng, Meizhu…[et al.]. 2017. Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation. Neural Plasticity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193328
Modern Language Association (MLA)
Xia, Shuang…[et al.]. Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation. Neural Plasticity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1193328
American Medical Association (AMA)
Xia, Shuang& Song, TianBin& Che, Jing& Li, Qiang& Chai, Chao& Zheng, Meizhu…[et al.]. Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193328