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Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients
Joint Authors
Vallorani, Luciana
Gioacchini, Anna Maria
Casadei, Lucia
Piccoli, Giovanni
Stocchi, Vilberto
Agostini, Deborah
Lucertini, Francesco
Annibalini, Giosuè
Passalia, Annunziata
Del Sal, Marta
Andreani, Mauro
Federici, Ario
Barbieri, Elena
Guescini, Michele
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes (T2D) is an age-related chronic disease associated with metabolic dysregulation, chronic inflammation, and activation of peripheral blood mononuclear cells (PBMC).
The aim of this study was to assess the effects of a concurrent exercise training program on inflammatory status and metabolic parameters of T2D patients.
Sixteen male patients (age range 55–70) were randomly assigned to an intervention group (n=8), which underwent a concurrent aerobic and resistance training program (3 times a week; 16 weeks), or to a control group, which followed physicians’ usual diabetes care advices.
Training intervention significantly improved patients’ body composition, blood pressure, total cholesterol, and overall fitness level.
After training, plasma levels of adipokines leptin (−33.9%) and RBP4 (−21.3%), and proinflammatory markers IL-6 (−25.3%), TNF-α (−19.8%) and MCP-1 (−15.3%) decreased, whereas anabolic hormone IGF-1 level increased (+16.4%).
All improvements were significantly greater than those of control patients.
Plasma proteomic profile of exercised patients showed a reduction of immunoglobulin K light chain and fibrinogen as well.
Training also induced a modulation of IL-6, IGF-1, and IGFBP-3 mRNAs in the PBMCs.
These findings confirm that concurrent aerobic and resistance training improves T2D-related metabolic abnormalities and has the potential to reduce the deleterious health effects of diabetes-related inflammation.
American Psychological Association (APA)
Annibalini, Giosuè& Lucertini, Francesco& Agostini, Deborah& Vallorani, Luciana& Gioacchini, Anna Maria& Barbieri, Elena…[et al.]. 2017. Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194484
Modern Language Association (MLA)
Annibalini, Giosuè…[et al.]. Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194484
American Medical Association (AMA)
Annibalini, Giosuè& Lucertini, Francesco& Agostini, Deborah& Vallorani, Luciana& Gioacchini, Anna Maria& Barbieri, Elena…[et al.]. Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194484