Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate
Joint Authors
Vikram, Ajit
Tikoo, Kulbhushan
Shrivastava, Shweta
Jena, Gopabandhu
Shah, Heta
Chhabra, Richa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Obesity and dietary habits are associated with increased incidences of aging-related prostatic diseases.
The present study was aimed to investigate transgenerational effects of chronic high-fat diet (HFD) feeding on inflammation and senescence-related changes in prostate.
Methods.
Sprague-Dawley rats were kept on either normal or HFD one.
Senescence-associated β-galactosidase (SA β-gal) activity, inflammation, and cellular proliferation were determined in the prostate.
Results.
Increased SA β-gal activity, expression of p53, and cell proliferation marker PCNA were observed in ventral prostate of HFD-fed rats.
Immunostaining for p53 and PCNA revealed that the p53 immunopositive cells were primarily in stroma while PCNA immunopositive cells were epithelial cells.
An increase in expression of cycloxygenase-2 (COX-2) and phosphorylation of nuclear factor-kappa B (NF-kB) was observed in prostate of weaning pups HFD-fed parents.
However, in adult pups, irrespective of dietary habit, a significant increase in the expression of COX-2, PCNA, phosphorylation of NF-kB, infiltration of inflammatory cells, and SA β-gal activity was observed.
Conclusions.
Present investigation reports that HFD feeding promotes accumulation of p53 expressing cells, proliferation of epithelial cells, and senescence-related changes in prostate.
Further, parental HFD-feeding upholds inflammatory, proliferative, and senescence-related changes in prostate of pups.
American Psychological Association (APA)
Tikoo, Kulbhushan& Vikram, Ajit& Shrivastava, Shweta& Jena, Gopabandhu& Shah, Heta& Chhabra, Richa. 2017. Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194825
Modern Language Association (MLA)
Tikoo, Kulbhushan…[et al.]. Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194825
American Medical Association (AMA)
Tikoo, Kulbhushan& Vikram, Ajit& Shrivastava, Shweta& Jena, Gopabandhu& Shah, Heta& Chhabra, Richa. Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194825